College of Medicine
Abisambra Lab
Led by Jose F. Abisambra · Neuroscience
What we study
The Abisambra Lab studies how the protein tau causes problems in cells by disrupting RNA translation, the process that makes proteins. They use molecular experiments to discover why tau leads to diseases like Alzheimer’s, frontotemporal dementia, and CTE.
What working here is like
- Wet lab
- Projects
- 3
- Papers
- 5
Current projects
The impact of tau on RNA and translation in progressive supranuclear palsy
Studying how tau affects RNA and protein synthesis in progressive supranuclear palsy.
Pathological Implications of the tau-RNA Interaction
Examining how abnormal tau binding to RNA contributes to disease.
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Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia
Investigating how tau‑driven problems in protein production drive frontotemporal dementia.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity
2026 · Journal of Neuroscience
Compares two versions of a protein called PERK to see how they affect tau protein in brain diseases.
- PERK deficiency amplifies molecular, structural, and network vulnerability to repetitive mild traumatic brain injury
2026 · Neurobiology of Disease
Checks how a protein called PERK affects brain damage from repeated head injuries.
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- The Interactions of Tau, RNA, and Stress Granules in Neurodegenerative Disease: A Comprehensive Review
2026 · Cells
Reviews how RNA and proteins interact in diseases like ALS and Alzheimer's.
- Spatial mapping of the brain metabolome lipidome and glycome
2025 · Nature Communications
Developed a method to map brain metabolites, lipids, and sugars in tissue sections using mass spectrometry.
- Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy
2025 · Molecular Neurodegeneration
Looks for changes in blood proteins in people with head injuries to understand brain damage.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Jose F. Abisambra hasn't set up this page yet. Their UF Scholars profile lists their publications.