College of Medicine
Alonge Lab
Led by Kimberly M. Alonge · Neuroscience
What we study
The Alonge Lab studies how the brain’s extracellular matrix, especially perineuronal nets, changes shape and chemistry and how that affects neuron activity in health and disease. They use advanced imaging and liquid mass spectrometry on rodent brains to map sulfation patterns and aim to apply findings to humans.
What working here is like
- Wet lab
- Projects
- 2
- Papers
- 4
Current projects
Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment
Studying how maternal immune challenges alter GAG sulfation in developing brains.
Control of energy and glucose homeostasis by hypothalamic perineuronal nets
Investigating how hypothalamic perineuronal nets regulate energy balance and glucose.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Hyperglycosylation is a metabolic driver of Alzheimer’s disease
2026 · Nature Metabolism
Discovered that too much sugar in the brain is linked to Alzheimer's disease.
- Adaptive oligodendrogenesis regulates blood-hypothalamus barrier permeability, hypothalamic glucose sensing and systemic glucose homeostasis in male mice
2026 · Molecular Metabolism
Showed that brain cells can sense blood sugar levels and adjust accordingly.
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- Biphasic remodeling of arcuate nucleus perineuronal nets in diet-induced obese mice
2026 · Molecular Metabolism
Found that high-fat diets change the structure of brain cells in obese mice over time.
- Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations
2025 · Molecular Metabolism
Showed that a protein can change brain cells' activity and behavior over time.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Kimberly M. Alonge hasn't set up this page yet. You can also look them up in the UF directory (search “Kimberly M. Alonge”).