College of Medicine
Bhaduri-McIntosh Lab
Led by Sumita Bhaduri-McIntosh · Pediatrics
What we study
The lab studies Epstein-Barr virus (EBV), which causes infectious mononucleosis and is linked to cancers. Researchers explore how EBV disrupts cell growth and how it persists in most people, aiming to find new treatments.
What working here is like
- Wet lab
- Projects
- 3
- Papers
- 5
Current projects
Understanding viral mechanisms to inform oncolytic therapies for EBV-associated lymphomas in PLWH
Exploring how EBV causes lymphomas in people with HIV to develop new treatments.
Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
Identifying weaknesses in EBV-positive lymphomas to target with new therapies.
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Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
Finding ways to kill EBV-positive lymphomas by exploiting their dependencies.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma
2026 · Frontiers in Immunology
Shows how STING restricts Kaposi's sarcoma-associated herpesvirus reactivation in lymphoma cells.
- Playing both sides – Epstein-Barr Virus accumulates select cellular transcripts to counter virus-mediated host shut-off in lytic cells
2026 · PLoS Pathogens
Finds that Epstein-Barr virus preserves some host genes while suppressing others during infection.
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- Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication
2026 · Journal of Medical Virology
Tests whether nanatinostat triggers full Epstein-Barr virus replication in lymphoma cells.
- Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein–Barr virus in diffuse large B-cell lymphomas
2025 · NAR Cancer
Examines why some EBV-positive lymphoma cells fail to fully reactivate the virus.
- STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas
2025 · PLoS Pathogens
Identifies how STAT3, MYC, and EBNA1 work together to promote EBV-positive lymphoma growth.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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