College of Medicine
Biodefense/Bioterrorism Therapeutic Countermeasures Laboratory (BBTC)
Led by Henry S Heine · Medicine
What we study
The BBTC lab studies antibiotics and treatments for bioterrorism agents like Yersinia pestis. They test drugs in mice and use special equipment to mimic how people get infected, like through breathing in bacteria.
What working here is like
- Wet lab
- Mice
- Bacteria & microbes
- Projects
- 2
- Papers
- 5
Current projects
The Development and Use of a Murine Aerosol Challenge Model for Influenza Infection
Creating a way to test influenza treatments in mice by exposing them to airborne virus.
In vitro biological evaluation of polymyxin analogs versus category A and B pathogens
Testing new versions of polymyxin antibiotics against dangerous bacteria.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Tolfenpyrad Modulates Antibiotic Activity on Francisella novicida and Synergizes with Electron Transport Chain Inhibitors
2026 · ACS Infectious Diseases
Finds how tolfenpyrad works with other antibiotics against Francisella.
- Teixobactin: A Resistance-Evading Antibiotic for Treating Anthrax
2025 · ACS Infectious Diseases
Tests teixobactin as a treatment for anthrax-resistant bacteria.
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- Genomic insights into ceftazidime resistance in Burkholderia pseudomallei : discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating penA duplication and amplification
2025 · Antimicrobial Agents and Chemotherapy
Identifies genetic changes that make Burkholderia resistant to ceftazidime.
- Tolfenpyrad Derivatives Exhibit Potent Francisella-Specific Antibacterial Activity without Toxicity to Mammalian Cells In Vitro
2024 · ACS Infectious Diseases
Tests whether pesticide derivatives can kill Francisella bacteria without harming human cells.
- Evaluation of a potent LpxC inhibitor for post-exposure prophylaxis treatment of antibiotic-resistant Burkholderia pseudomallei in a murine infection model
2024 · Antimicrobial Agents and Chemotherapy
Evaluates a drug to treat Burkholderia infections in mice.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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