College of Medicine
Bloom Lab
Led by David C Bloom · Molecular Genetics and Microbiology
What we study
The Bloom Lab studies how herpes simplex virus (HSV) hides in nerve cells (latency) and wakes up again, using a human neuron cell model it developed (LUHMES). Projects look at viral RNAs and chromatin during latency, reactivation in single cells, and gene-therapy approaches to recurrent HSV disease.
What working here is like
- Wet lab
- Cells in a dish
- Projects
- 3
- Papers
- 4
Current projects
Analyzing interactions between viral lncRNAs and cellular proteins
Studies how viral long non-coding RNAs interact with cell proteins during herpes simplex virus latency in nerve cells.
Studying the mechanism of HSV reactivation at the single cell level
Examining how HSV reactivation happens in individual neurons.
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Development and commercialization of novel gene therapy approaches
Develops gene therapy approaches for recurring herpes simplex virus infections, with work toward turning them into real treatments.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Dynamics of Paraspeckle Components in Herpes Simplex Virus 1 (HSV-1)-Infected Human Neuronal Cells
2026 · Viruses
Studies how herpes virus affects paraspeckles in human neurons.
- Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster
2026 · Microbiology Resource Announcements
Sequences a severe herpes virus strain from a young child.
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- Anti-HSV-1 activity and Na+, K+-ATPase modulation from extracts and nanoemulsions of Myrciaria floribunda leaves
2026 · Journal of Applied Microbiology
Tests if leaf extracts block herpes virus growth by affecting ion pumps.
- Analysis of host and viral nascent and steady-state RNA levels in a human neuronal model of herpes simplex virus 1 infection
2026 · PLoS Pathogens
Tracks RNA activity in neurons before and after herpes virus infection.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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