Public Health and Health Professions
Brant Lab
Led by Jason O Brant · Biostatistics
What we study
The Brant Lab studies how DNA methylation and chromatin structure affect gene expression and disease, using mouse models and computational tools. They develop methods for analyzing epigenomic data and apply them to cancer and sepsis research.
What working here is like
- Wet lab
- Computational
- Mice
- Coding helps
- Projects
- 2
- Papers
- 5
Current projects
Epigenetic consequences of acute physiological stress
Studying how heat stroke affects immune cells' DNA methylation and function.
Chromatin remodeling in sepsis and critical illness
Examining immune cell changes in sepsis patients to predict long-term outcomes.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- FENGC: Targeted, Multiplexed, and Integrated Single-Molecule Profiling of Chromatin Accessibility and DNA Methylation
2026 · Methods in molecular biology
- A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells
2026 · Frontiers in Immunology
Used a new method to study how sepsis changes gene activity in immune cells, showing differences by age and sex.
Show 3 more papersShow fewer
- A Defined 3D Hydrogel Model Recapitulates Key Transcriptomic Features of Lung Adenocarcinoma
2026 · Tissue Engineering Part C Methods
Builds a 3D hydrogel model that better mimics lung cancer biology than traditional 2D cultures.
- Defined bacterial consortium highlights the impact of intestinal bacteria on DNA methylation and tumorigenesis
2026 · Genome biology
Shows how different gut bacteria affect DNA methylation and tumor growth in mice with colitis.
- Transcriptomic Analyses of Normal Human Pancreata Reveal the Presence of Cancer Subtypes that Correlate with Acinar Ductal Metaplasia and Donor Ancestry
2025 · Cancer Research Communications
Found two types of normal pancreatic cells, linked to changes in gene activity and donor background.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Jason O Brant hasn't set up this page yet. You can also look them up in the UF directory (search “Jason O Brant”).