College of Medicine
Law Lab
Led by Brian Law · Pharmacology and Therapeutics
What we study
The Law Lab studies cyclin-dependent kinases (Cdks) in breast cancer and chromosomal instability, using models to test therapeutic strategies like Cdk inhibitors and upstream signaling pathways. They also research novel anticancer agents targeting death receptors and protein disulfide isomerases.
What working here is like
- Wet lab
- Cells in a dish
- Coding helps
- Projects
- 4
- Papers
- 5
Current projects
Mechanisms by which CDCP1 Promotes Breast Cancer Metastasis
Researching how CDCP1 facilitates cancer cell invasion and metastasis.
Activation of Death Receptors 4 and 5 by Altered Disulfide Bonding as a New Approach to Cancer Therapy
Exploring novel anticancer agents that disrupt disulfide bonds to activate death receptors.
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Identification of the First Active Site Inhibitors of the Disulfide Isomerases ERp44 and AGR2 as Novel Anticancer Agents
Developing inhibitors for protein disulfide isomerases to target cancer cells.
Project Blocking the Oncogenic Wnt Signaling Pathway for Cancer Therapy Using a Novel Small Molecule
The lab will identify the ~50 kDa protein that binds to the chaperone MESD after treatment with disulfide‑disrupting agents and will show how this interaction affects the folding of Wnt receptors, aiming to shut down the Wnt/β‑catenin pathway that drives colorectal and breast cancers.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 312
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- CerS2 Is a Druggable Target in Triple-Negative Breast Cancer
2026 · Molecular Cancer Therapeutics
Finds a new drug that kills cancer cells by boosting a specific enzyme.
- Non-Canonical, Strongly Selective Protein Disulfide Isomerases as Anticancer Therapeutic Targets
2025 · Biomolecules
Reviews how certain enzymes in cells could be targeted to fight cancer.
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- Assessing cancer therapeutic efficacy in vivo using [ 2 H 7 ]glucose deuterium metabolic imaging
2025 · Science Advances
Develops a way to see how cells use sugar for energy in living tumors.
- The Role of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Signaling in Cancer
2025 · Cells
Explains how a protein helps cancer cells grow and spread.
- DR5 Disulfide Bonding Functions as a Sensor and Effector of Protein Folding Stress
2025 · Molecular Cancer Research
Tests whether breaking disulfide bonds in DR5 protein can kill cancer cells without harming normal tissues.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Brian Law hasn't set up this page yet. Their UF Scholars profile lists their publications.