College of Medicine
Cai Lab
Led by Guoshuai Cai · Surgery
What we study
The Cai Lab studies myeloid-derived suppressor cells (MDSCs) in sepsis and critical illness, focusing on their role in immune responses and potential interventions. They use experimental approaches to understand these cells' effects.
- Project
- 1
- Papers
- 5
Current projects
Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention of Chronic Critical Illness after Sepsis
Investigating MDSCs' role in immune responses and potential treatments for chronic illness after sepsis.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells
2026 · Frontiers in Immunology
Maps epigenetic changes in MDSCs after sepsis in mice, focusing on age and sex differences.
- Preterm birth skews the developmental trajectory of myeloid-derived suppressor cells in the first 48 hours of life: single-cell transcriptomics and inferred intercellular communication
2026 · Molecular Medicine
Uses single-cell transcriptomics to study how preterm birth affects MDSCs in the first 48 hours of life.
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- Independent Multi-Cohort RNA-Seq Analysis Does Not Support Recurrent DNAJB1::PRKACA Fusion in Hepatoblastoma or Biliary Atresia. Comment on Fleifil et al. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers 2025, 17, 83
2026 · Cancers
- CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo
2026 · Cell Reports Medicine
Tests whether CDK8/19 inhibitors can prevent resistance to CDK4/6 inhibitors in breast cancer.
- Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability
2026 · Cancer Epidemiology Biomarkers & Prevention
Finds lung cancer susceptibility copy number variants and their role in genetic instability.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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