College of Dentistry
Caudle Lab
Led by Robert M Caudle · Oral and Maxillofacial Surgery
What we study
The Caudle Lab studies pain mechanisms in the knee and jaw, focusing on nerve signals and how opioids and cannabinoids affect pain. They also investigate understudied nerve receptors in facial pain.
- Projects
- 3
- Papers
- 5
Current projects
Innervation of the knee and TMJ
Maps the nerve supply to the knee and jaw joint to understand how pain signals arise there.
Role of Understudied aGPCRs in Orofacial Neuropathic Pain
Studies lesser-known nerve receptors, called adhesion GPCRs, and their role in chronic facial nerve pain.
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Opioid and cannabinoid interactions in pain and reward
Studies how opioids and cannabinoids interact in pain and reward, using nerve signal research on pain mechanisms.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Cannabidiol reduces oxycodone self-administration while preserving its analgesic efficacy in a rat model of neuropathic pain
2026 · Scientific Reports
Tests if CBD reduces oxycodone use while keeping pain relief in rats with nerve damage.
- CRISPR Epigenome Editing of IL1R1 Expression of Neurons that Innervate the Temporomandibular Joint or Knee Causes Reduced Sensitization to Osteoarthritic Environment
2026 · Annals of Biomedical Engineering
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- Advanced tissue clearing and three-dimensional imaging approaches to visualize neural innervation in the rat knee joints
2026 · npj Imaging
Develops new methods to visualize nerve fibers in rat knee joints using tissue clearing.
- Spontaneously hypertensive rats exhibit reduced facial pain sensitivity with altered electrophysiology and transcriptomics in the trigeminal ganglia
2026 · Journal of Pain
Shows spontaneously hypertensive rats have lower facial pain sensitivity with altered nerve activity.
- Mitochondrial and Autophagy‐Related Proteins are Downregulated in the Brains of the rTg4510 Mouse Model of Tauopathy and Associated with Pain‐like Behavior in a Sex‐Dependent Manner
2025 · Alzheimer s & Dementia
Finds mitochondrial and autophagy proteins are lower in tauopathy mice and may affect pain.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Robert M Caudle hasn't set up this page yet. Their UF Scholars profile lists their publications.