College of Dentistry
Cha Lab
Led by Seunghee Cha · Oral and Maxillofacial Diagnostic Sciences
What we study
The Cha Lab studies Sjögren's disease, an autoimmune disease of the salivary and tear glands: how cells sense their own mitochondrial RNA in childhood Sjögren's, and whether targeting P2 receptors can restore gland function.
- Projects
- 2
- Papers
- 5
Current projects
PKR sensing of mitochondrial dsRNA in childhood Sjogrens disease
Investigates how mitochondrial dsRNA is sensed in Sjogren's syndrome.
Targeting P2 receptors to restore salivary and lacrimal gland function in sjogren's syndrome
Explores P2 receptor targeting to improve gland function in Sjogren's syndrome.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Comparative evaluation of 16S rRNA sequencing strategies reveals superior resolution of the healthy Korean salivary microbiome by full-length sequencing
2026 · Scientific Reports
Compares methods for studying the Korean oral microbiome and finds a better approach.
- Backtracking identification techniques for predicting unclear bacterial taxonomy at species level: molecular diagnosis-based bacterial classification
2025 · Genes & Genomics
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- Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjögren disease
2025 · RMD Open
Tests whether mitochondrial RNA in saliva and plasma links to immune responses in Sjögren disease.
- SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases
2025 · Cell Reports
Finds SLIRP amplifies antiviral signals from mitochondrial RNA in autoimmune diseases.
- Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren’s disease
2025 · Rheumatology
Studies a gene linked to inflammation in children with Sjögren's disease.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Seunghee Cha hasn't set up this page yet. Their UF Scholars profile lists their publications.