College of Veterinary Medicine
The Vulpe Lab
Led by Chris Vulpe · Physiological Sciences
What we study
The Vulpe Lab studies how environmental chemicals and stressors affect organisms from yeast to humans, using CRISPR screens and genetic approaches to uncover toxicity mechanisms.
What working here is like
- Wet lab
- Computational
- Yeast
- Cells in a dish
- Coding helps
- Projects
- 3
- Papers
- 6
Current projects
Long-Term Health Impacts of Harmful Algal Blooms Study
Studies the long-term health effects on people of harmful algal blooms, as part of the lab's work on how environmental stressors affect health.
CRISPR screens of population relevant genes governing toxicant resilience
Uses CRISPR screens to find genes that help cells withstand toxic chemicals.
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Identifying the Gene Expression Phenotype of FRDA
Researchers turned stem cells into heart cells to study Friedreich’s Ataxia, a disease that hurts the heart. They used RNA sequencing to compare gene activity in normal, disease, and control cells, hoping to find targets for future treatments.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 258
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Primary prevention of Parkinson’s disease: proceedings, the 8C’s and a position statement from the Parkinson’s disease prevention think tank
2026 · npj Parkinson s Disease
Discusses steps to prevent Parkinson’s disease.
- A pilot study of urinary biomarkers and kidney injury among agricultural workers
2026 · BMC Nephrology
Tests urine markers to spot kidney problems in sugarcane workers.
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- Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
2026 · Molecular Neurodegeneration
Finds that iron buildup in brain cells may harm neurons and astrocytes in Parkinson's disease.
- Iron Deficiency-Induced Hair Loss Is Associated with ROS-Mediated Disruption of Wnt/β-Catenin Signaling
2026 · Nutrients
Shows how iron deficiency in mothers can cause hair loss in babies, possibly due to damaged cell signals.
- A Genome-Wide CRISPR Screen Identifies C18orf32 as a Novel Modulator of PFOA-Induced Cytotoxicity and Lipid Dysregulation
2026 · Environmental Health Perspectives
Uses gene editing to find ways to protect liver cells from toxic chemicals.
- Additional file 1 of Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
2026 · Figshare
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Chris Vulpe hasn't set up this page yet. Their UF Scholars profile lists their publications.