College of Veterinary Medicine
Cooke Lab
Led by Paul S Cooke · Physiological Sciences
What we study
The Cooke Lab studies how the hormone 17α-estradiol extends health span and lifespan differently in males and females, focusing on effects that do not act through genes directly.
- Project
- 1
- Papers
- 4
Current projects
Unraveling nongenomic mechanisms by which 17a-estradiol extends health span and longevity in a sex-specific manner
Investigating how estrogen affects health span and longevity outside of genetic changes.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- 2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia
2026 · Advanced Healthcare Materials
Shows niclosamide reduces endometriosis and pain by targeting immune cells.
- Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice
2025 · Biology of Sex Differences
Finds estrogen receptors help protect neurons from Alzheimer’s damage.
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- Advances in Drug Treatments for Companion Animal Obesity
2024 · Biology
Explores using human obesity drugs for pet weight loss.
- Role for Nongenomic Estrogen Signaling in Male Fertility
2023 · Endocrinology
Shows membrane estrogen receptors help male fertility.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Paul S Cooke hasn't set up this page yet. Their UF Scholars profile lists their publications.