College of Pharmacy
Cristofoletti Lab
Led by Rodrigo Cristofoletti · Pharmaceutics
What we study
The Cristofoletti Lab uses in vitro systems and modeling to study drug absorption, interactions, and disease effects, focusing on gut and brain systems. They develop microphysiological systems like intestine-on-a-chip to predict drug behavior.
What working here is like
- Wet lab
- Computational
- Coding helps
- Projects
- 5
- Papers
- 5
Current projects
Smart Trop-2 CAR-T with Synthetic Circuits for TNBC Precision
Designs CAR-T cells, engineered immune cells, with built-in synthetic gene circuits that target Trop-2, to improve precision treatment of triple-negative breast cancer.
Vascularized fetal liver-hematopoietic niche-on-chip to decode erythroid dysregulation in Down syndrome
Builds a chip-based model of fetal liver tissue with blood vessels to study how red blood cell development goes wrong in Down syndrome.
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Quantitative Systems Pharmacology (QSP) Research Project
Builds quantitative systems pharmacology models, computer models of how a drug acts within the body's systems, to study drug effects and disease.
Improving translatability of drug-drug interactions arising from CYP induction for drugs with low Km using carbamazepine as a CYP…
Uses carbamazepine to improve how well lab data on drug interactions caused by enzyme induction predict what happens in patients.
Vibrio microcins. A hidden field of targeted anti-cholerae natural products
Studies Vibrio microcins, natural antibacterial compounds, as targeted treatments against cholera-causing bacteria.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Biowaiver monograph for immediate-release solid oral dosage forms: Dabigatran etexilate
2026 · Journal of Pharmaceutical Sciences
- Quantitative Characterization of Innate and Adaptive Pharmacology of Allogeneic anti-CD20 Chimeric Antigen Receptor (CAR) Vδ1 γδ T cells using Multiscale Mechanistic Modeling
2026 · The AAPS Journal
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- Mechanistic mass transport analysis of dissolution of weak-base drugs considering the influence of surface pH in formulations with and without acidifying agents
2026 · Frontiers in Pharmacology
Analyzes how pH affects drug dissolution in weak-base medications.
- Integrating Static and Dynamic Models to Predict Cannabidiol‐Mediated Metabolic Drug–Drug Interactions
2026 · Clinical Pharmacology & Therapeutics
Tests whether CBD affects drug metabolism using different models to predict interactions.
- Toward a Platform PBPK Model to Characterize the Plasma and Tissue Disposition of Unconjugated Antisense Oligonucleotides and GalNAc ‐Conjugated Small Interfering RNAs in Preclinical Species and Human
2026 · Clinical Pharmacology & Therapeutics
Develops a model to track how unconjugated antisense drugs and siRNAs move in the body across species.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Rodrigo Cristofoletti hasn't set up this page yet. Their UF Scholars profile lists their publications.