College of Medicine
Ostrov Lab
Led by David Ostrov · Pathology
What we study
The Ostrov Lab studies islet neoantigens in Type 1 diabetes, focusing on identifying and understanding new immune targets in human islets. They use experimental approaches to uncover mechanisms of autoimmune destruction in diabetes.
What working here is like
- Wet lab
- Computational
- No organisms (data only)
- Coding required
- Projects
- 2
- Papers
- 5
Current projects
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
Identifying new immune targets in human islets to understand autoimmune destruction in Type 1 diabetes.
Development and Validation of Novel Small Molecule Inhibitors for the HIRA/H3.3 Pathway in Castration-Resistant Prostate Cancer
Researchers will screen 139,735 compounds with computer docking to find molecules that block the UBN1/H3.3 interaction, aiming to create new drugs for prostate cancers that no longer respond to hormone therapy.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 321
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells
2026 · Archives of Toxicology
Uses CRISPR to find genes that protect liver cells from PFOS damage.
- Discovery of a pyridine-piperazine-based small molecule that enhances the activity of peptidase neurolysin
2026 · Journal of Pharmacology and Experimental Therapeutics
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- Antihypertensive drug-induced liver injury is rare, but strongly associated with HLA-B∗35:01
2026 · Acta Pharmaceutica Sinica B
Finds HLA-B*35:01 strongly linked to liver damage from blood pressure drugs.
- HLA-A*32:01 and Lamotrigine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms
2026 · JAMA Network Open
Links HLA-A*32:01 to severe reactions from lamotrigine.
- Therapeutic Efficacy of Targeting HLA-DR3 Using A Spontaneous Humanized Mouse Model of Sjögren’s Disease 3606
2025 · The Journal of Immunology
Tests whether targeting HLA-DR3 in mice can treat Sjögren’s disease.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
David Ostrov hasn't set up this page yet. Their UF Scholars profile lists their publications.