Agricultural and Life Sciences (IFAS)
de Crécy-Lagard Lab
Led by Valerie de Crecy-Lagard · Microbiology and Cell Science
What we study
The lab studies how small changes in RNA and metabolism affect cell function, using computer analysis and experiments. They focus on rare RNA modifications and their effects on bacteria and yeast.
What working here is like
- Wet lab
- Computational
- Bacteria & microbes
- Yeast
- Coding helps
- Projects
- 2
- Papers
- 5
Current projects
Role of complex RNA modification in integration of translation and metabolism
Exploring how missing RNA modifications affect cell division and protein function in bacteria and yeast.
Q modification and metal homeostasis
Investigating how Q modification affects sensitivity to metals like cadmium and nickel in bacteria.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations
2026 · Open Biology
Maps tRNA modifications in two types of bacteria.
- Functional divergence and conservation in the QueC protein family (PF06508): from tRNA modification to anti-phage defense
2026 · Biochemical Journal
Explores how a protein family adapts to new functions.
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- Characterization of a Heme-Binding Radical SAM Enzyme HemW from Moraxella catarrhalis
2026 · ACS Bio & Med Chem Au
Studies a protein that helps bacteria survive low iron.
- Quantitative RNA modification mapping by mass spectrometry with isobaric tags and nucleobase fragment analysis
2026 · Nature Communications
Creates a tool to map RNA modifications in bacteria.
- Pyridoxal-phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA
2026 · Nature Chemical Biology
Identifies an enzyme that modifies tRNA to decode isoleucine.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Valerie de Crecy-Lagard hasn't set up this page yet. Their UF Scholars profile lists their publications.