College of Medicine
Dinculescu Lab
Led by Astra Dinculescu · Ophthalmology
What we study
The lab studies Usher syndrome type 3 (USH3), a genetic disorder causing hearing and vision loss, by examining the CLRN1 protein in Müller glia cells. They aim to develop gene-therapy treatments using AAV vectors to prevent blindness in patients.
What working here is like
- Wet lab
- Project
- 1
- Papers
- 4
Current projects
Clarin-1 retinal function and therapeutic implications for USH3
How the CLRN1 protein works in retinal Müller glia, to design safe gene therapy for Usher syndrome type 3.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors
2025 · PLoS Genetics
Tests whether deleting a gene region in zebrafish affects photoreceptor health and stress response.
- A Modified Arrestin1 Increases Lactate Production in the Retina and Slows Retinal Degeneration
2022 · Human Gene Therapy
Uses a modified protein to boost lactate production in photoreceptors and slow degeneration.
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- Distinct Phenotypic Consequences of Pathogenic Mutants Associated with Late-Onset Retinal Degeneration
2022 · American Journal Of Pathology
Shows how a gene mutation causes thick deposits in the retina and affects aging.
- Retinal Gene Therapy for Usher Syndrome: Current Developments, Challenges, and Perspectives
2021 · International Ophthalmology Clinics
Reviews current gene therapy approaches for Usher syndrome and their challenges.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Astra Dinculescu hasn't set up this page yet. Their UF Scholars profile lists their publications.