College of Medicine
Mitchell Lab
Led by Duane Mitchell · Neurosurgery
What we study
The Mitchell Lab studies brain tumors, focusing on immunotherapy and precision treatments. They develop novel therapies for children and adults with malignant brain tumors, combining epigenetic and immune approaches.
What working here is like
- Wet lab
- Clinical
- Human participants
- Cells in a dish
- No coding
- Projects
- 5
- Papers
- 5
Current projects
Addressing tumor heterogeneity in pediatric gliomas with precision adoptive T cell therapy
Developing personalized immune therapies for pediatric brain tumors.
Combining Epigenetic Therapy and Immunotherapy to Target Group 4 Medulloblastoma
Combining epigenetic drugs and immune therapies for aggressive brain tumors.
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Adoptive Cellular Therapy Targeting Recurrent/Progressive Oligodendroglioma
Using immune cells to target recurrent oligodendrogliomas, a type of brain tumor.
Precision mEdicine and Adoptive Cellular tHerapy for the treatment of recurrent neuroblastoma and newly diagnosed diffuse…
Personalized immune therapies for neuroblastoma and DIPG, a rare brain tumor.
Enhancing mRNA-based immunotherapy exploring polyadenylation and silencing of mRNA nucleosides
The lab is working to improve mRNA vaccines for brain cancer. This project tests whether a longer poly(A) tail helps immune cells make more of the encoded protein before the mRNA breaks down.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 154
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Improving Immune Checkpoint Blockade Efficacy in Melanoma Brain Metastases through Myddosomal Inhibition with Emavusertib
2026 · Molecular Cancer Therapeutics
Tests a new drug to boost immune responses in brain cancer.
- Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors
2025 · Journal for ImmunoTherapy of Cancer
Tests if dog cancer vaccines can help brain tumors.
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- CTIM-01. INCREASED BLOOD–TUMOR TCR REPERTOIRE OVERLAP CORRELATES WITH FAVORABLE CLINICAL RESPONSES IN CHILDREN WITH RECURRENT MEDULLOBLASTOMA TREATED WITH ADOPTIVE CELL TRANSFER THERAPY
2025 · Neuro-Oncology
Finds that more tumor-reactive T cells in children with medulloblastoma correlate with better responses to adoptive cell therapy.
- DDEL-13. Enhanced CNS delivery of therapeutic nanoparticles with focused ultrasound improves treatment efficacy in glioblastoma
2025 · Neuro-Oncology
Shows how focused ultrasound can improve delivery of mRNA nanoparticles to brain tumors in mice.
- TMIC-55. Tumor mRNA delivery via microgel-chemokine-mRNA (MCM) complex reprograms microglia and induces glioma regression through CCL4-CCR5 axis
2025 · Neuro-Oncology
Tests whether a microgel-chemokine-mRNA complex can reprogram microglia and shrink gliomas in mice.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Duane Mitchell hasn't set up this page yet. You can also look them up in the UF directory (search “Duane Mitchell”).