Liberal Arts and Sciences
Eddy Lab
Led by Matthew Eddy · Chemistry
What we study
The Eddy Lab studies how G protein‑coupled receptors (GPCRs) interact with cell membranes and lipids, using biophysical experiments and chemical‑biology tools. They also create protein‑polymer conjugates to make more stable biologic drugs.
What working here is like
- Wet lab
- Projects
- 2
- Papers
- 2
Current projects
In situ GPCR fragment molecule screening approach with HRMAS NMR
Developing a method to screen GPCR fragments directly in their native membrane environment using solid‑state NMR.
Project Magnesium impacts the stability and function formation of a stimulatory signaling protein and its disease-associated variants
The lab uses biophysical tools to study how magnesium influences the thermal stability and activity of the GαS signaling protein and its disease‑linked variants, finding that magnesium lowers stability especially with GDP and that mutations near the magnesium site affect stability and GTP activation.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 467
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition
2023
Studying how negatively charged lipids influence how GPCRs bind to G proteins.
- Membrane Mimetic-Dependence of GPCR Energy Landscapes
2023
Examining how different membrane mimics alter the energetic states of GPCRs.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Matthew Eddy hasn't set up this page yet. Their UF Scholars profile lists their publications.