College of Medicine
Efron Lab
Led by Philip A Efron · Surgery
What we study
The lab studies inflammation and immunology in severe injury and infection, focusing on how these processes contribute to poor outcomes in ICU patients. Research involves basic and translational studies, including collaborations with other researchers.
What working here is like
- Wet lab
- Clinical
- Human participants
- Projects
- 4
- Papers
- 5
Current projects
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
Investigates how myeloid cells contribute to poor outcomes after sepsis.
Sepsis and the Systemic Cytokine Storm in Aging and Alzheimer Disease Models
Explores the link between sepsis and neurodegenerative diseases.
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Molecular Biology in Burns and Trauma
Studies the molecular changes in the body after severe burns and trauma, to understand why some patients do poorly in intensive care.
Pathological Myeloid Activation After Sepsis and Trauma
Examines how myeloid cells become dysfunctional after sepsis and trauma.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- The Microbiome in Critical Illness
2026 · Critical Care Medicine
Reviews how the microbiome affects critically ill or injured patients and their treatments.
- Moderate pediatric burn injury is associated with reduced monocyte HLA-DR expression and heightened whole-blood LPS-induced TNF-α responses
2026 · Frontiers in Pediatrics
Finds that moderate pediatric burns lower monocyte HLA-DR expression and increase LPS-induced TNF-α responses.
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- A single-cell atlas of human neutrophils reveals neutrophil heterogeneity across health and disease
2026 · Nature Immunology
Creates a single-cell atlas of human neutrophils to study their different roles in health and disease.
- β-Blockade reprograms trauma-induced changes in bone marrow exosomal microRNAs
2026 · The Journal of Trauma: Injury, Infection, and Critical Care
Tests whether propranolol can restore bone marrow function by changing microRNA levels in trauma-injured rats.
- Molecular Subtypes in Acute Respiratory Illness and Sepsis
2026 · Seminars in Respiratory and Critical Care Medicine
Reviews how molecular subtypes in acute respiratory illness and sepsis can help identify different treatment effects.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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