Liberal Arts and Sciences
Tang Lab
Led by Feng Tang · Chemistry
What we study
The Tang Lab studies how DNA damage occurs and is repaired across the human genome. They use high‑throughput DNA sequencing, mass‑spectrometry, chemical biology tools, and machine‑learning‑based data analysis to map where and how lesions appear.
What working here is like
- Wet lab
- Computational
- Cells in a dish
- Coding helps
- Projects
- 2
- Papers
- 3
Current projects
Exploring Shieldin Loss and Therapy Resistance in BRCA-Deficient Cancers
The lab studies how loss of the Shieldin complex lets BRCA1/2‑mutant cancer cells avoid death from PARP inhibitors. Students will use CRISPR and repair reporter assays to find new DNA repair pathways and screen for drug targets that could overcome this resistance.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 333
Glycation and Epigenetic Reprogramming in Cancer Cells: Investigating DNA Methylation and Histone Modifications
The lab examines how sugar‑derived damage (glycation) changes DNA methylation in breast cancer cells. They grow MCF‑7 cells with and without methylglyoxal, extract DNA for bisulfite sequencing, and plan to use LC‑MS/MS to look at glycation on proteins and histones.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 330
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- DNA polymerase κ participates in early S-phase DNA replication in human cells
2024 · Proceedings of the National Academy of Sciences
Investigating the role of polymerase κ in early DNA replication in human cells.
- DNA–Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol
2022 · Journal of the American Chemical Society
Developing a sequencing method to map thymidine glycol DNA‑protein cross‑links across the genome.
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- Polymerase η Recruits DHX9 Helicase to Promote Replication across Guanine Quadruplex Structures
2022 · Journal of the American Chemical Society
Studying how polymerase η and DHX9 helicase help replicate through guanine‑quadruplex DNA structures.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Feng Tang hasn't set up this page yet. You can also look them up in the UF directory (search “Feng Tang”).