College of Medicine
Clarke Lab
Led by Harrison Clarke · Pathology(unverified)
What we study
The Clarke Lab studies metabolism in lung cancer and the brain using spatial metabolomics. A recent student project follows tumors in a KRAS and p53 mutant mouse model with 7 Tesla MRI, then maps metabolites in tumor sections with MALDI imaging.
What working here is like
- Wet lab
- Mice
- Coding helps
- Project
- 1
- Papers
- 5
Current projects
Mapping Tumor Metabolism in Lung Adenocarcinoma Using Spatial Imaging and Advanced Metabolomics
Using a KRAS‑ and p53‑mutant mouse model, the lab monitors tumor growth with 7 Tesla MRI and then maps metabolites in tumor sections with MALDI‑MSI to reveal metabolic changes that could serve as biomarkers or therapy targets.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 286
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Machine-Learning-Based Prediction of Clinical Outcomes in Gliomas Using Glycomic Features
2026 · Computational and Structural Biotechnology Journal
Uses sugar patterns in brain tumors to predict patient survival.
- Hyperglycosylation is a metabolic driver of Alzheimer’s disease
2026 · Nature Metabolism
Finds that extra sugar attachments in brain cells may cause Alzheimer's.
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- AI-driven framework to map the brain metabolome in three dimensions
2025 · Nature Metabolism
- Glycogen drives tumour initiation and progression in lung adenocarcinoma
2025 · Nature Metabolism
- Spatial mapping of the brain metabolome lipidome and glycome
2025 · Nature Communications
Maps sugar, fat, and small molecules in brain tissue.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Harrison Clarke hasn't set up this page yet. You can also look them up in the UF directory (search “Harrison Clarke”).