College of Medicine
Ildefonso Lab
Led by Cristhian J Ildefonso · Ophthalmology
What we study
The Ildefonso Lab studies how antisense oligonucleotides (ASOs) could treat retinal diseases like Retinitis Pigmentosa, using the Rho(T17M) mouse model. They test ASOs to see if they can improve vision in these mice.
What working here is like
- Wet lab
- Mice
- Project
- 1
- Papers
- 5
Current projects
Testing antisense oligonucleotides in the Rho(T17M) mouse model of retinitis pigmentosa
Testing whether antisense oligonucleotides can slow vision loss in a mouse model of retinitis pigmentosa.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Rescuing the light sensors: Functional recovery in PROM1 knockout models via photoreceptor-specific promoters
2026 · Molecular Therapy
- Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy
2025 · Scientific Reports
Shows how an anti-inflammatory gene therapy delays retinal damage in a mouse model.
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- EPO-R76E Enhances Retinal Pigment Epithelium Viability Under Mitochondrial Oxidative Stress Induced by Paraquat
2025 · Cells
Tests if a modified erythropoietin variant protects retinal cells from oxidative stress.
- Binocular benefit following monocular subretinal AAV injection in a mouse model of autosomal dominant retinitis pigmentosa (adRP)
2023 · Vision Research
Tests if a gene therapy works across species to prevent retinal degeneration.
- Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness
2023 · Science Advances
Tests if increasing proteasome activity slows vision loss in a blindness model.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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