Herbert Wertheim College of Engineering
Immuno-Modulatory Biomaterials Laboratory (IMBL)
Led by Jamal Lewis · Biomedical Engineering
What we study
The Lewis Lab studies how to design materials that control the immune system. They create tiny particles to treat autoimmune diseases and explore how immune cells react to these materials. Work involves making and testing biomaterials, studying immune cells, and understanding how drugs interact with the immune system.
What working here is like
- Wet lab
- Projects
- 3
- Papers
- 5
Current projects
Development of a particulate platform system for autoimmune disease therapy
Designs a particle-based therapy that retrains the immune system to treat autoimmune diseases.
Understanding controlled non-lytic exocytosis in phagocytic cells
Exploring how immune cells release substances without breaking open.
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Uncovering the role of dendritic cells in the foreign body response to materials
Studies how immune cells called dendritic cells react to foreign materials such as implants, so biomaterials can be designed to work better.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Controlled Delivery of Immunomodulatory Factors for Mineralized Tissue Formation in an Inflammatory Microenvironment (Adv. Healthcare Mater. 4/2026)
2026 · Advanced Healthcare Materials
Shows that controlled release of immunomodulatory factors can promote bone healing.
- Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model
2026 · PLoS ONE
Tests if Mpr1-functionalized nanoparticles can deliver antifungal drugs to brain cells.
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- Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells
2025 · Heliyon
Identifies signaling networks linked to lactate's effect on immune cells in cancer.
- Controlled Delivery of Immunomodulatory Factors for Mineralized Tissue Formation in an Inflammatory Microenvironment
2025 · Advanced Healthcare Materials
Shows that controlled delivery of immunomodulatory factors can help MSCs heal bones.
- Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses
2025 · Frontiers in Immunology
Tests if PSA nanoparticles can safely treat food allergies without anaphylaxis.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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