College of Medicine
Ishov Lab
Led by Alexander M Ishov · Physiology and Aging
What we study
The Ishov Lab studies how histone variants and proteins like Daxx influence cancer progression, focusing on prostate and breast cancers. They use experiments to understand epigenetic changes and drug resistance.
What working here is like
- Wet lab
- Projects
- 3
- Papers
- 5
Current projects
Functions of histone variants in castration-resistant prostate cancer
Investigating how histone variants affect prostate cancer progression and drug resistance.
Chemoresistance in breast cancer
Examining Daxx protein's role in taxane resistance and mitotic progression in breast cancer.
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Tumor suppression function of Daxx
Studying Daxx's role in suppressing tumor metastasis and invasion.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Overcoming ABCB1 mediated multidrug resistance in castration resistant prostate cancer
2024 · Cell Death and Disease
Tests whether blocking ABCB1 can help taxane drugs work better in prostate cancer.
- Genome-Wide Methylation Profiling of Peripheral T–Cell Lymphomas Identifies TRIP13 as a Critical Driver of Tumor Proliferation and Survival
2024 · Epigenomes
Looks at DNA methylation in T-cell lymphomas to find genes linked to tumor growth.
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- HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
2023 · Nucleic Acids Research
Shows how H3.3 histone variant helps androgen receptor control gene expression.
- Inhibition of Mps1 kinase enhances taxanes efficacy in castration resistant prostate cancer
2022 · Cell Death and Disease
Tests whether blocking Mps1 kinase makes taxane drugs work better in prostate cancer.
- Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator
2021 · Nucleic Acids Research
Shows how super-enhancers regulate β-globin gene expression in mice and humans.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Alexander M Ishov hasn't set up this page yet. Their UF Scholars profile lists their publications.