College of Medicine
Bruno Translational Cardio-Immunology Laboratory
Led by Katelyn Bruno · Medicine
What we study
The lab studies heart diseases like myocarditis and heart failure, using animal models, human samples, and data to find new treatments and biomarkers. They focus on how sex and age affect immune responses in heart diseases.
What working here is like
- Wet lab
- Clinical
- Mice
- Coding helps
- Projects
- 5
- Papers
- 6
Current projects
Investigation into presentation and progression of pediatric myocarditis
Compares immune responses in viral myocarditis between children and adults, using a mouse model and clinical samples to see the roles of sex, age and hormones.
Sex differences in the immune response in hypermobile Ehlers-Danlos syndrome and hypermobility syndrome disorders
Examining how sex affects immune responses in these conditions.
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Elucidating the innate and adaptive immune mechanism differences during viral myocarditis between pediatric and adult…
Comparing immune responses in pediatric and adult viral myocarditis, focusing on sex, age, and hormones.
Effects of Stem-Cell Derived Therapy on Myocarditis in Translational Animal Model
The lab tests whether a mixture of proteins and particles from fat‑derived stem cells can reduce heart inflammation in mice infected with a virus that causes myocarditis. The student prepared the stem‑cell secretome, gave it to mice, and measured inflammation and viral levels.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 223
The Effect of Sex Hormones and Sex Chromosomes in Coxsackievirus B3 Myocarditis Utilizing Four Core Genotype Mice
Researchers infected 8‑week‑old Four Core Genotype mice with coxsackievirus B3 and examined heart tissue, finding that wild‑type female mice had less inflammation than other groups, indicating both hormones and chromosomes influence myocarditis severity.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 198
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Prevalence of Intracranial and Cervical Artery Abnormalities in Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Presenting to an Academic Headache Clinic
2026 · Neurology International
Checks for artery abnormalities in hypermobile patients at a headache clinic.
- Females with hypermobile Ehlers–Danlos syndrome self-report more sexual problems than chronic pain controls without hypermobility, males, or patients with hypermobile spectrum disorders
2026 · Frontiers in Reproductive Health
Shows women with hypermobility report more sexual issues than others.
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- Twenty years of sex and gender science in health research: a policy statement from the Organization for the Study of Sex Differences
2026 · Biology of Sex Differences
Outlines best ways to study sex and gender in health research.
- Inducible Laryngeal Obstruction in Hypermobile Patients
2026 · The Laryngoscope
Compares symptoms in hypermobile patients with and without laryngeal issues.
- Age-related symptom clustering in pediatric hypermobility spectrum disorders: a scoping review
2026 · Orphanet Journal of Rare Diseases
Reviews early signs of pediatric hypermobility disorders.
- Additional file 2 of Age-related symptom clustering in pediatric hypermobility spectrum disorders: a scoping review
2026 · Figshare
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Katelyn Bruno hasn't set up this page yet. Their UF Scholars profile lists their publications.