College of Medicine
Keeler Lab
Led by Geoffrey D Keeler · Pediatrics
What we study
The lab studies gene therapy for metabolic disorders and immune tolerance in diseases like multiple sclerosis using gene delivery methods and animal models.
What working here is like
- Wet lab
- Projects
- 2
- Papers
- 5
Current projects
Combined pharmacologic and AAV gene therapy of pyruvate dehydrogenase deficiency
Pairing drugs with AAV gene therapy for a rare metabolic disorder.
Restoring immune tolerance in a model of multiple sclerosis
Using gene delivery to retrain the immune system in a multiple sclerosis model.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- A Rationally Designed AAV9-DM Capsid with Minimal Liver Tropism
2026 · Cells
Creates a new virus vector with less liver damage.
- Fecal AAV8 shedding and co-housing reduces EAE disease severity: implications for preclinical study design
2026 · Frontiers in Medicine
Finds that sharing cages with mice exposed to a virus reduces disease severity.
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- Upregulation of CD8+ regulatory T cells following liver-directed AAV gene therapy
2024 · Cellular Immunology
Finds that liver-directed gene therapy increases CD8+ regulatory T cells in mice.
- Enhanced transgene expression from single-stranded AAV vectors in human cells in vitro and in murine hepatocytes in vivo
2024 · Molecular Therapy — Nucleic Acids
Shows how a gene sequence in AAV2 vectors boosts gene delivery in human cells and mice.
- Development of capsid- and genome-modified optimized AAVrh74 vectors for muscle gene therapy
2023 · Molecular Therapy — Methods & Clinical Development
Develops modified AAVrh74 vectors for muscle gene therapy.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Geoffrey D Keeler hasn't set up this page yet. Their UF Scholars profile lists their publications.