College of Medicine
Khanna Lab
Led by Rajesh Khanna · Pharmacology and Therapeutics
What we study
The Khanna Lab studies how voltage-gated ion channels regulate pain and nerve function in chronic pain and neurodegenerative diseases. They use mouse genetics, microscopy, electrophysiology, and behavioral tests to explore these mechanisms.
What working here is like
- Wet lab
- Mice
- Rats
- Projects
- 5
- Papers
- 5
Current projects
Validation of Neuropilin-1 Receptor Signaling in Nociceptive Processing
Exploring how Neuropilin-1 receptors influence pain signaling in nerve cells.
Fibronectin Modulation of Oral Cancer Nociception
Investigating how fibronectin affects pain in oral cancer patients.
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Dissection of NTSR2/calcium channel signaling as a non-opioid spinal analgesic mechanism for the treatment of high impact chronic pain
Studying NTSR2 receptors and calcium channels to develop non-opioid pain treatments.
Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy
Researching Schwann cell repair to treat chemotherapy-induced nerve pain.
Validation of a Nonopioid Analgesic Pathway in Human Sensory Ganglia and Spinal Cord
Identifying non-opioid pain pathways in human nerve cells and spinal cord.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Parabrachial Npy1r ‐Expressing Neurons Drive Pain in a Mouse Model of Parkinson's Disease
2026 · Movement Disorders
Finds parabrachial neurons with a specific receptor drive pain in a mouse model of Parkinson's disease.
- Parabrachial neuropeptide Y Y1 receptor–expressing neurons govern the sensory dimension of neuropathic pain
2026 · Pain
Shows that parabrachial neurons with a specific receptor control pain sensitivity in nerve injury.
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- Activating glial GPR37L1 to resolve neuropathic pain
2026 · Pain
- Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics
2026 · Journal of Clinical Investigation
Shows that muscle overactivity causes persistent pain, which can be treated with specific drugs.
- Spared but Not Silent: Ion Channel Plasticity in Uninjured Sensory Neurons in Neuropathic Pain
2026 · International Journal of Molecular Sciences
Explores how uninjured nerve cells contribute to chronic pain after nerve damage.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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