College of Medicine
Khodayari Lab
Led by Nazli Khodayari · Medicine
What we study
The Khodayari Lab studies how a genetic disorder called Alpha-1 Antitrypsin Deficiency causes inflammation and tissue damage in the liver and lungs. They explore how tiny cell messengers called extracellular vesicles contribute to these problems and look for ways to treat them.
What working here is like
- Wet lab
- Mice
- Papers
- 5
Recent papers, explained
- Polymerized Z-α-1 antitrypsin leads to lung injury in a murine model of emphysema
2026 · JCI Insight
Shows Z-AAT polymers cause lung injury and emphysema in a murine model of AAT deficiency.
- Alpha-1 antitrypsin modulates neutrophil phenotype and function: implications for inflammatory regulation
2025 · Journal of Leukocyte Biology
Shows alpha-1 antitrypsin maintains neutrophil polarity and migration in inflammation.
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- Neutrophil-derived extracellular vesicles in the plasma of alpha-1 antitrypsin deficient individuals reveal pro-inflammatory metabolic and transcriptomic signatures
2025 · Extracellular Vesicle
Analyzes neutrophil dysfunction in alpha-1 antitrypsin deficiency using RNA sequencing and metabolomics.
- Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice
2025 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Finds pioglitazone reduces ZAAT accumulation and improves liver health in AATD mice.
- Lung Inflammation in Alpha-1-Antitrypsin Deficient Individuals with Normal Lung Function
2022
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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