College of Medicine
Kladde Lab
Led by Michael Kladde · Biochemistry and Molecular Biology
What we study
The Kladde Lab studies how genes are turned on and off by changes in chromatin (nucleosomes, histone modifications, and DNA methylation). They develop tools like MAPit to map these changes and apply them to cancer and viral infections.
What working here is like
- Wet lab
- Computational
- Coding helps
- Projects
- 4
- Papers
- 4
Current projects
Epigenetic Method and Tool Development
Developing tools like MAPit to map DNA methylation and chromatin accessibility.
Aberrant Epigenetic Detection
Using nucleosome sensors to detect abnormal chromatin states and SWI/SNF remodeling activity.
Show 2 more projectsShow fewer
Epigenetics in Sepsis
Investigating how epigenetic changes contribute to severe sepsis and chronic illness.
Epigenetics in Cancer
Studying how epigenetic silencing drives cancer development and drug resistance.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells
2026 · Frontiers in Immunology
Maps epigenetic changes in immune cells after sepsis, showing age and sex differences.
- Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm
2025 · Epigenetics
Tests how tributyltin chloride affects sperm, finding structural and epigenetic changes.
Show 2 more papersShow fewer
- Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury
2025 · Shock
Profiles macrophages after burns, showing early silencing of inflammatory genes and later anti-inflammatory changes.
- Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness
2024 · Frontiers in Immunology
Uses single-cell RNA sequencing to compare immune cells in healthy and septic patients.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Michael Kladde hasn't set up this page yet. Their UF Scholars profile lists their publications.