College of Medicine
Nguyen Lab
Led by Lien Nguyen · Molecular Genetics and Microbiology
What we study
The Nguyen Lab studies how repetitive DNA sequences, called tandem repeats, cause diseases like Alzheimer's and ALS. They use advanced sequencing and computational tools to identify and analyze these repeats in patient samples and animal models.
What working here is like
- Wet lab
- Computational
- Clinical
- Human participants
- Coding helps
- Projects
- 6
- Papers
- 5
Current projects
Studying contribution of repeat variants of SVA retrotransposons in Alzheimer's disease
Examining how SVA retrotransposon repeats contribute to Alzheimer's disease.
Studying mechanisms that CASP8 GGGAGA repeat expansion variants increase Alzheimer's risk
Investigating how CASP8 GGGAGA repeat expansions increase Alzheimer's disease risk.
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Novel repeat associated non-AUG (RAN) proteins in sALS, sFTD and SBMA: shared pathological features and unifying therapeutic opportunities
Studying RAN proteins in ALS, FTD, and SBMA to find shared disease mechanisms and potential treatments.
Studying roles of CASP8 SVA GGGAGA repeat expansions in Alzheimer's disease
Exploring how CASP8 SVA GGGAGA repeat expansions contribute to Alzheimer's disease.
Contribution of CASP8 GGGAGA repeat expansion in Alzheimer's disease
Analyzing the role of CASP8 GGGAGA repeat expansions in Alzheimer's disease.
Association of hexanucleotide repeat expansion in SVA elements and Alzheimer's Disease
The team measured the length of a specific DNA repeat in two genes in 1,589 Alzheimer’s patients and 1,919 controls, finding that repeats of 40 in PJA2 and repeats of 20 in HGSNAT are linked to higher disease risk.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 385
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Repeat expansion RNA elicits toxicity through hybrid G-quadruplexes with promoter DNA
2026 · Neuron
- Studying the role of CASP8 GGGAGA repeat expansion in Alzheimer's disease
2025 · Alzheimer s & Dementia
Tests whether a gene variant linked to Alzheimer's disease affects brain cells in lab models.
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- polyGR produced by CASP8 GGGAGA repeat expansion increases phosphorylation of Tau
2025 · Alzheimer s & Dementia
Finds that a gene variant in Alzheimer's disease increases brain damage by making tau proteins sticky.
- PolyGR‐Containing Aggregates in Alzheimer's Disease: A Novel Proteinopathy Associated with Clinical Features of AD Patients
2025 · Alzheimer s & Dementia
Finds new protein clumps in Alzheimer's brains linked to brain damage and high blood pressure.
- PolyGR‐containing aggregates link with AD pathological hallmarks and autophagy pathway
2025 · Alzheimer s & Dementia
Shows how gene variants in Alzheimer's disease link to protein clumps and brain damage.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Lien Nguyen hasn't set up this page yet. Their UF Scholars profile lists their publications.