College of Pharmacy
Luesch Lab (CNPD3)
Led by Hendrik Luesch · Medicinal Chemistry
What we study
The Luesch Lab explores marine natural products to discover new drugs, focusing on chemical synthesis, target identification, and drug development. They study compounds like dolastatin 10 and gatorbulin-1 for cancer and other diseases.
What working here is like
- Wet lab
- Computational
- Marine organisms
- Coding helps
- Project
- 1
- Papers
- 5
Current projects
Gatorbulin-1
A novel marine natural product discovered from cyanobacteria blooms off the Florida coast.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer (Adv. Sci. 42/2026)
2026 · Advanced Science
Designs new compounds that activate antioxidant pathways and block inflammation.
- Effect of an Ulva lactuca Extract on Systemic Antioxidant and Inflammatory Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
2026 · Nutrients
Shows sea lettuce extract reduces inflammation and boosts antioxidants in humans.
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- Characterization of Dapalides D and E and Genomic Comparison of the Two Co-Occurring Dapalide-Producing Dapis spp.
2026 · Journal of Natural Products
Identifies new compounds from marine cyanobacteria and their biosynthetic genes.
- Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation
2026 · Proceedings of the National Academy of Sciences
Finds the biosynthetic pathway for an anticancer drug in marine cyanobacteria.
- Marine Actin-Associated Agents Cause Distinct In Vivo Neuromuscular, Epithelia, and Organogenesis Phenotype Profiles in Caenorhabditis elegans
2026 · Journal of Natural Products
Tests how marine compounds affect muscle, skin, and development in worms.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Hendrik Luesch hasn't set up this page yet. Their UF Scholars profile lists their publications.