College of Medicine
Maile Lab
Led by Rob Maile · Surgery
What we study
The Burn Lab studies immune system dysfunction after burns and trauma, using mouse models, cell culture, and clinical samples. They explore mechanisms of infection risk, immune recovery, and chronic suppression to improve patient outcomes.
What working here is like
- Wet lab
- Clinical
- Mice
- Cells in a dish
- Human participants
- Projects
- 4
- Papers
- 5
Current projects
Defining an immunosuppressive index that predicts infection susceptibility after burn injury
Aims to build a measurable immune index that predicts which burn patients are most likely to develop infections, using patient samples and immune measurements.
Determine the role and associated mechanisms of mTOR/PPAR axis in the innate immune cell pathophysiology observed after burn and…
Exploring how the mTOR/PPAR pathway affects immune dysfunction after burns.
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NRF2 is insufficient in preventing pulmonary damage after burn and inhalation injury
Investigating why NRF2 fails to protect lungs from damage after burns.
Immunomodulatory extracellular vesicles arise after burn and polytraumatic injuries
Studying how extracellular vesicles affect immune responses after burns.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Preterm birth skews the developmental trajectory of myeloid-derived suppressor cells in the first 48 hours of life: single-cell transcriptomics and inferred intercellular communication
2026 · Molecular Medicine
Uses advanced techniques to study immune cells in premature babies and how they differ from full-term babies.
- Optimization of Preclinical Rodent Research Models of Human Shock: Part 2 Trauma, Burn, and the Gut Microbiome
2026 · Shock
Reviews how mouse models of trauma and burns can help study human responses and test treatments.
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- Dissecting bone marrow and plasma exosomal microRNA profiles following trauma
2026 · Surgery
- Moderate pediatric burn injury is associated with reduced monocyte HLA-DR expression and heightened whole-blood LPS-induced TNF-α responses
2026 · Frontiers in Pediatrics
Finds that moderate burns in kids weaken immune cells and make them more reactive to infection.
- β-Blockade reprograms trauma-induced changes in bone marrow exosomal microRNAs
2026 · The Journal of Trauma: Injury, Infection, and Critical Care
Shows that a drug, propranolol, may restore normal bone marrow function after trauma by changing tiny RNA messages.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Rob Maile hasn't set up this page yet. Their UF Scholars profile lists their publications.