College of Medicine
Corti Lab
Led by Manuela Corti · Pediatrics
What we study
The Corti Lab studies Friedreich's ataxia, a genetic disorder, using gene therapy and tracking brain/spinal cord changes in patients. They focus on improving treatment safety and efficacy through immunomodulation.
What working here is like
- Clinical
- Wet lab
- Human participants
- Mice
- Coding helps
- Projects
- 3
- Papers
- 5
Current projects
Immunomodulation Approaches to Improve Safety And Efficacy of Gene Therapy Treatment in Friedreich’s Ataxia
Researching ways to enhance gene therapy safety and effectiveness for Friedreich's ataxia patients.
A natural history study to TRACK brain and spinal cord changes in individuals with Friedreich Ataxia
Monitoring brain and spinal cord changes in Friedreich's ataxia patients to understand disease progression.
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Restoration of Cardiac and Neurological Functions in Friedreich’s Ataxia Mouse Models via rAAV Based Gene Therapy with Endogenous Promoter‑Controlled Frataxin E
Researchers are testing a new gene‑therapy vector that delivers the human frataxin gene to mice that model Friedreich’s ataxia. Students will help inject the vector into newborn mice, monitor survival, measure frataxin levels, and test heart and motor function.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 484
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- A deep learning framework for automated cervical spinal cord vertebral labeling and morphometric extraction from brain MRI with large-scale multicenter validation
2026 · npj Digital Medicine
Builds a deep learning tool to label spinal cord vertebrae in brain MRI scans.
- Geometric brain signatures for characterising hereditary ataxia and predicting functional brain organisation: a retrospective multicohort study
2026 · The Lancet Medical Imaging & Theranostics
Tests whether brain shape differences help spot hereditary ataxia early.
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- Neonatal gene therapy normalizes respiratory patterns in Pompe rats
2026 · Physiology
Tests gene therapy to fix breathing problems in Pompe disease rats.
- Assessing airway clearance dysfunction in Friedreich’s ataxia: A focus on peak cough flow
2026 · Journal of Neuromuscular Diseases
Measures cough strength in Friedreich’s ataxia to check for breathing issues.
- Modeling the Budget Impact of Disease-Modifying Therapies in Infantile-Onset Spinal Muscular Atrophy
2026 · Clinical Drug Investigation
Estimates costs of new treatments for spinal muscular atrophy over five years.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Manuela Corti hasn't set up this page yet. Their UF Scholars profile lists their publications.