College of Medicine
Moehle Lab
Led by Mark Moehle · Pharmacology and Therapeutics
What we study
The Moehle Lab studies how brain changes in disorders like Parkinson’s and dystonia affect movement and behavior. They use mouse models and techniques like fiber photometry to explore cellular and circuit-level changes, aiming to develop new treatments.
What working here is like
- Wet lab
- Mice
- Coding required
- Projects
- 3
- Papers
- 5
Current projects
Cholinergic Mechanisms in Lewy Body Dementia
Exploring how acetylcholine signaling affects cognitive decline in Lewy Body Dementia.
M5 modulators to treat or modify the motor symptoms of Parkinson’s Disease
Testing compounds that could improve motor symptoms in Parkinson’s Disease.
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Pathological α‑Synuclein Perturbs Nuclear Integrity
Using mouse models and high‑resolution microscopy, the lab showed that disease‑related α‑synuclein forms aggregates inside cell nuclei, leading to abnormal nuclear shapes, increased DNA damage, and altered nuclear envelope repair proteins. The student performed the imaging and data analysis.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 176
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- M5 positive allosteric modulation alleviates parkinsonian motor deficits
2026 · PLoS ONE
Tests whether a drug called M5 can help with Parkinson's disease symptoms.
- Rigorous evaluation of pathological α-synucleinopathy transmissibility between animals in an experimental model
2026 · Acta Neuropathologica Communications
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- Robust tauopathy and memory deficits in a mouse model constitutively overexpressing human P301L MAPT
2026 · Neurobiology of Disease
Shows that a mouse model with a tau protein mutation causes memory problems.
- Pathological α-synuclein perturbs nuclear integrity
2025 · Neurobiology of Disease
Tests whether pathological α-synuclein harms the nucleus in brain cells.
- Early α-synuclein aggregation decreases corticostriatal glutamate drive and synapse density
2025 · Neurobiology of Disease
Shows early α-synuclein buildup weakens brain signals and connections.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Mark Moehle hasn't set up this page yet. Their UF Scholars profile lists their publications.