College of Veterinary Medicine
Mathews Lab
Led by Clayton Mathews · Infectious Diseases and Immunology
What we study
The Mathews Lab studies type 1 diabetes and sepsis: how immune cells attack insulin-making beta cells, and how faulty blood-cell production worsens sepsis. Current grants use human pancreas slices and look for new immune targets in the islets.
- Projects
- 3
- Papers
- 5
Current projects
Renewal: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
This project studies how immune cells worsen sepsis by impairing blood cell production.
Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices
Researchers examine how diabetes affects insulin-producing cells using human pancreas tissue.
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Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
The lab identifies new immune targets in diabetes using human pancreas samples.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Tissue Data Explorer: a website template for presenting tissue sample research findings
2026 · The Journal of Open Source Software
Creates a website template to display and share research data from tissue samples.
- A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells
2026 · Frontiers in Immunology
Maps epigenetic changes in immune cells after sepsis to understand long-term immune dysfunction.
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- Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches
2026 · Journal of Interferon & Cytokine Research
Explains how MDA5 protein structure affects its role in detecting viral RNA and triggering immune responses.
- Enhancement of cytokine-mediated beta-cell apoptosis by free fatty acids
2026 · Cell Communication and Signaling
Investigates how fats contribute to beta cell death in type 1 diabetes using human islet samples.
- Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background
2026 · iScience
Uses gene editing to study how a protective gene variant affects pancreatic islet function in diabetes.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Clayton Mathews hasn't set up this page yet. Their UF Scholars profile lists their publications.