College of Medicine
Gentry Lab
Led by Matthew Gentry · Biochemistry and Molecular Biology
What we study
The Gentry Lab studies brain metabolism and glycogen storage diseases like Lafora disease, using experiments to understand disease mechanisms and develop therapies targeting glycogen metabolism.
What working here is like
- Wet lab
- Mice
- Coding helps
- Projects
- 3
- Papers
- 5
Current projects
Lafora Epilepsy Cure Initiative (LECI)
A global consortium studying Lafora disease mechanisms and developing therapies targeting glycogen.
Brain Glycogen – Metabolism, Mechanisms, and Therapeutic Potential
Studies how the brain stores and uses glycogen, a form of sugar, and how defects in this process cause diseases like Lafora disease, to find possible therapies.
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Project Evaluation of a novel brain-targeting therapeutic for the treatment of multiple neurological Glycogen Storage Diseases
The lab tests a brain‑penetrant antibody‑GAA fusion that targets the transferrin receptor in mouse models of Pompe and Lafora disease. The student will administer the drug biweekly for four weeks and measure brain glycogen levels and metabolism.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 570
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains
2026 · Cell Reports Medicine
Links glycogen changes in Alzheimer's brains to disease stage and brain regions.
- Autolysosomal enhancer GHF201 attenuates pathophysiology in a mucopolysaccharidosis type I mouse model
2026 · Life Science Alliance
Tests if GHF201 can help treat a genetic disorder by boosting cell recycling.
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- S -Nitrosylation of glycogen phosphorylase regulates nuclear glycogenolysis and is impaired in metabolic liver disorders
2026 · Science Advances
Finds nitric oxide controls glycogen breakdown in liver cells, affecting disease.
- Hyperglycosylation is a metabolic driver of Alzheimer’s disease
2026 · Nature Metabolism
Shows sugar buildup in Alzheimer's brains may drive disease progression.
- Fucose supplementation as a novel treatment approach for GLUT1 deficiency syndrome
2026 · Journal of Neurology
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Matthew Gentry hasn't set up this page yet. You can also look them up in the UF directory (search “Matthew Gentry”).