College of Medicine
McIntosh Lab
Led by Michael McIntosh · Pediatrics
What we study
The lab studies viruses and infectious diseases using advanced molecular biology, bioinformatics, and sequencing to detect pathogens, understand host-microbial interactions, and develop diagnostic tools and vaccines.
What working here is like
- Wet lab
- Computational
- Coding helps
- Papers
- 5
Recent papers, explained
- Playing both sides – Epstein-Barr Virus accumulates select cellular transcripts to counter virus-mediated host shut-off in lytic cells
2026 · PLoS Pathogens
Finds Epstein-Barr virus preserves some host genes despite shutting off most.
- Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication
2026 · Journal of Medical Virology
Shows nanatinostat triggers full Epstein-Barr virus lytic cycle in lymphoma cells.
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- Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein–Barr virus in diffuse large B-cell lymphomas
2025 · NAR Cancer
Tests whether lytic stimuli reactivate Epstein-Barr virus in DLBCL cell lines.
- STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas
2025 · PLoS Pathogens
Shows STAT3, MYC, and EBNA1 work together to regulate EBV-positive lymphoma growth.
- Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas
2024 · Journal of Virology
Suggests polymerase theta could kill EBV lymphomas by targeting error-prone DNA repair.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
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