College of Pharmacy
He Lab
Led by Mei He · Pharmaceutics
What we study
The He Lab studies extracellular vesicles and exosomes to develop new therapies for cancer, autoimmune diseases, and infections. They use microfluidics, nanotechnology, and AI to isolate and load these vesicles with precision.
What working here is like
- Wet lab
- Computational
- No organisms (data only)
- Mice
- Coding required
- Projects
- 5
- Papers
- 5
Current projects
ExoRelease kit
A commercialized tool for isolating extracellular vesicles to speed up diagnostic and therapeutic development.
CRISPR gene therapy
Developing extracellular vesicle-based CRISPR gene therapy through ExoDeL Inc.
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Project Bovine placental-derived natural bio-ink for the development of a deep wound healing hydrogel
The lab makes a hydrogel from cow placenta and amniotic fluid vesicles that can be 3‑D printed into droplets. Students will test how fast the collagen gels and how the vesicles help wounds heal compared to other cell‑based vesicles.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 369
IL-2 Loaded Extracellular Vesicles Provide High Efficiency Treatment of Type 1 Diabetes
The lab proposes giving IL‑2 orally inside extracellular vesicles to boost regulatory T cells and reverse type 1 diabetes in NOD mice, hoping to reduce side effects seen with systemic IL‑2. They will optimize loading to create a high‑efficiency, gut‑absorbed delivery platform.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 210
Leveraging the ExoQuality Index to Remove Extracellular Vesicle Isolate Bias from Breast Cancer Biomarker Detection
The lab develops a statistical tool to correct bias in tiny cell‑released particles used to find breast cancer markers. Students analyze public data sets to improve marker accuracy.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 84
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Microglia in autism spectrum disorder: heterogeneity, immunometabolism, and synapse-related pathways
2026 · Frontiers in Immunology
Reviews microglial changes in ASD, focusing on heterogeneity and synapse links.
- Urinary Extracellular Vesicles for High‐Precision Bladder Cancer Subtyping and Prognosis
2026 · Journal of Extracellular Biology
Uses AI-driven urinary EVs to subtype bladder cancer and predict survival.
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- Beyond BMI: central obesity identifies overlooked fatty liver disease risk in adults with normal body mass index undergoing routine health examinations
2026 · Frontiers in Public Health
Shows central obesity predicts fatty liver risk in people with normal BMI.
- Bovine placental-derived bio-ink reprograms tissue microenvironment for enhanced regeneration and senescence reversal
2026 · UF Journal of Undergraduate Research
Builds a bio-ink from bovine placenta and amniotic fluid for 3D printing wounds.
- Integrative functional genomics maps synaptic and developmental-regulatory autism risk-gene sets across human cortex
2026 · Functional & Integrative Genomics
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Mei He hasn't set up this page yet. Their UF Scholars profile lists their publications.