College of Medicine
Poulos Lab
Led by Michael Poulos · Medicine (Hematology and Oncology)
What we study
The Poulos Lab studies blood stem cells and the bone marrow niche in aging. A recent student project builds a lab-grown model of bone marrow blood-vessel cells to study alternative splicing; papers cover thrombospondin-1 and hematopoietic healthspan.
What working here is like
- Wet lab
- Cells in a dish
- No coding
- Project
- 1
- Papers
- 5
Current projects
Developing an ex vivo platform to examine alternative splicing within bone marrow endothelium
The lab builds a lab‑grown system of blood‑vessel cells from bone marrow to study how genes are cut and pasted differently. Students look at how these changes affect the cells’ role in blood‑cell production.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 126
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span
2025 · Science Immunology
Shows how blocking a protein called Thbs1 can reduce inflammation in blood stem cells and improve their health.
- Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow
2024 · Stem Cell Reviews and Reports
Builds a tool to study how different blood vessel cells in the bone marrow affect stem cells.
Show 3 more papersShow fewer
- Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response
2023 · Nature Communications
Finds that a protein called Netrin-1 keeps bone marrow cells young and helps old stem cells work better.
- 3015 – DELETION OF THROMBOSPONDIN-1 PRESERVES HEMATOPOIETIC STEM CELL HEALTHSPAN DURING AGING
2022 · Experimental Hematology
- 2003 – NETRIN-1 REJUVENATES THE AGED HEMATOPOIETIC STEM CELL NICHE BY RESTORING THE DNA DAMAGE RESPONSE.
2022 · Experimental Hematology
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Michael Poulos hasn't set up this page yet. Their UF Scholars profile lists their publications.