College of Medicine
Gumz Lab
Led by Michelle Gumz · Physiology and Aging
What we study
The Gumz Lab studies how the kidney's circadian clock affects blood pressure and kidney function, using rodent models to explore sex differences in clock proteins like PER1 and BMAL1. They investigate how the kidney clock interacts with adrenal glands and aging.
What working here is like
- Wet lab
- Computational
- Mice
- Coding required
- Projects
- 2
- Papers
- 5
Current projects
Renal and adrenal actions of the clock protein PER1 in salt-sensitive hypertension
Investigating how PER1 affects kidney and adrenal function in hypertension models.
Circadian Clock Gene Expression in the 4 Core Genotype Model
The lab looks at daily rhythm genes in mouse kidneys, comparing males and females to see how sex chromosomes and hormones affect gene patterns linked to kidney disease. The student used RNA data and qPCR to test these differences.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 134
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Loss of the Circadian Clock Protein Period 1 Mediates Sex‐Dependent Increase in Arterial Stiffness and Hypertrophic Remodeling in Mice
2026 · Journal of the American Heart Association
- Effect of adrenal-specific BMAL1 knockout on clock gene expression in the liver
2026 · UF Journal of Undergraduate Research
Checks if kidney disease affects the liver’s internal clock, using mice without adrenal BMAL1.
Show 3 more papersShow fewer
- High salt blunts time-of-day transcriptomic changes, affecting metabolic adaptations in salt-sensitive hypertension
2026 · Physiology
Finds that high salt disrupts the body’s internal clock, worsening blood pressure problems.
- Pkd1 Deficiency Causes Intrinsic Renal Circadian Clock Dysfunction.
2026 · PubMed
Shows how kidney disease slows down the body’s internal clock, speeding up cyst growth.
- Time of Day as a Biological Variable in Cardiovascular and Kidney Disease Research: A Scientific Statement From the American Heart Association
2026 · Arteriosclerosis Thrombosis and Vascular Biology
Explains how time of day affects research on heart and kidney diseases in humans and mice.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Michelle Gumz hasn't set up this page yet. You can also look them up in the UF directory (search “Michelle Gumz”).