College of Medicine
Mietzsch Lab
Led by Mario Mietzsch · Biochemistry and Molecular Biology
What we study
The Mietzsch Lab studies the structure of adeno-associated virus (AAV) and related parvoviruses, and engineers AAV gene-therapy vectors that can escape the antibodies many people already carry.
What working here is like
- Wet lab
- Project
- 1
- Papers
- 3
Current projects
Leaving no child behind: enabling universal access to AAV gene therapies by vector bio-engineering to evade pre-existing natural immunity
Engineering AAV vectors to bypass natural immunity for broader gene therapy applications.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Intracellular trafficking and nuclear compartmentalization of AAV gene delivery
2026 · Molecular Therapy Advances
Tracks how a gene therapy virus moves inside cells over time.
- Identification of human transferrin receptor as an entry co-receptor for parvovirus B19 infection of human erythroid progenitor cells
2026 · mBio
Identifies a protein that helps a virus enter bone marrow cells.
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- Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach
2026 · UNC Libraries
Uses cryo-EM to study how a virus's protein shell changes to infect different cells.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Mario Mietzsch hasn't set up this page yet. Their UF Scholars profile lists their publications.