College of Medicine
Narayan Lab
Led by Satya Narayan · Physiology and Aging
What we study
The Narayan Lab develops new cancer drugs by activating overlooked targets like CerS2, using human tumor models and small molecules to fight therapy-resistant cancers like TNBC and CRC.
What working here is like
- Wet lab
- Projects
- 2
- Papers
- 5
Current projects
Development of DH20931
Creating a first-in-class CerS2 agonist to treat therapy-resistant cancers.
Discovery of First-in-Class PP2A Activators
Developing PP2A activators to treat drug-resistant colorectal cancer.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Human-Centric Modeling in Metastatic Breast Cancer: Organoids, Organ-on-Chip Systems, and New Approach Methodologies in the Post-FDA Modernization Act 2.0 Era
2026 · Cancers
Reviews how human-centric models could improve metastatic breast cancer research.
- CerS2 Is a Druggable Target in Triple-Negative Breast Cancer
2026 · Molecular Cancer Therapeutics
Identifies DH20931 as a drug that activates CerS2 to kill triple-negative breast cancer cells.
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- CerS2-mediated lipotoxicity and calcium signaling: a novel sequential mechanism of apoptosis in cancer
2026 · Biochemical Journal
Explains how CerS2 mediates lipotoxicity and calcium signaling in cancer apoptosis.
- Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway
2024 · Mutagenesis
Shows that DNA ligase inhibitors slightly increase sensitivity to oxidative stress in cells with DNA polymerase β.
- Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer
2024 · Journal of Medicinal Chemistry
Tests whether a new compound, PPA24, can kill colorectal cancer cells and FOLFOX-resistant cells by boosting PP2A activity.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Satya Narayan hasn't set up this page yet. Their UF Scholars profile lists their publications.