College of Medicine
Subrahmanian Lab
Led by Nitya Subrahmanian · Neurology
What we study
The Subrahmanian Lab studies Parkinson's disease mechanisms. A recent student project tests how mild mitochondrial complex I deficits affect alpha-synuclein aggregation in disease models; its papers cover LRRK2, iron and oxidative stress in human neurons.
What working here is like
- Wet lab
- Cells in a dish
- Coding helps
- Project
- 1
- Papers
- 5
Current projects
Project Alpha-synuclein Dyshomeostasis is Exacerbated by Mitochondrial Complex I Dysfunction in Models of Parkinson’s Disease
The lab studies how mild mitochondrial complex I (CI) deficits affect alpha‑synuclein aggregation in Parkinson’s disease models. Students will create CI‑deficient cells using CRISPR‑Cas9 and shRNA, then measure alpha‑syn levels and aggregation after seeding with pre‑formed fibrils.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 515
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
2026 · Molecular Neurodegeneration
Shows LRRK2 mutations cause iron imbalance and oxidative stress in brain cells.
- Additional file 1 of Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
2026 · Figshare
Show 3 more papersShow fewer
- Regulation of LRRK2 activity by metabolic stress and heavy metal exposure
2025 · Brain Research
Finds LRRK2 activity changes with metabolic stress and metal exposure.
- The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons
2024 · Stem Cell Reports
Tests whether Rab8a and Rab10 affect LRRK2-related Parkinson’s disease.
- Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
2023 · Acta Neuropathologica Communications
Maps where Rab10 and its phosphorylated form are in the brain.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Nitya Subrahmanian hasn't set up this page yet. You can also look them up in the UF directory (search “Nitya Subrahmanian”).