College of Medicine
Chakrabarty Lab
Led by Paramita Chakrabarty · Neuroscience
What we study
The lab studies how the immune system affects brain diseases like Alzheimer's and Parkinson's. They test immune-based treatments in mouse models to slow disease progression.
What working here is like
- Wet lab
- Mice
- Coding required
- Projects
- 6
- Papers
- 5
Current projects
Exploration of Potential Treatments Targeting alpha-Synuclein
Testing immune-based therapies for diseases linked to alpha-synuclein proteins.
Sepsis and the Systemic Cytokine Storm in Aging and Alzheimer Disease Models
Studying how immune system responses contribute to Alzheimer's in aging mice.
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Deciphering tau phosphorylation and Abeta/tau strain interactions in Alzheimer’s pathogenesis
Examining how tau protein changes and interactions affect Alzheimer's progression in mice.
Modeling the progression of SOD1-linked motor neuron disease
Using mice to study how SOD1 mutations cause motor neuron diseases.
Exploring the Colocalization of ApoE Isoforms with Amyloid Beta Deposition within the SAA-APP Model
Scientists are studying how different human APOE proteins interact with amyloid‑beta plaques in a mouse model of Alzheimer’s disease. They found that the APOE4 protein is more likely to stick to plaques than APOE2, suggesting it may help plaques form.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 301
Effect of Sepsis-Associated Peripheral Inflammation on Alzheimer’s Disease Tau Pathology
Graduate students gave mice a sepsis injury and stress, then measured brain tau protein changes, finding that sepsis altered disease progression differently in male and female mice.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 121
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- PERK deficiency amplifies molecular, structural, and network vulnerability to repetitive mild traumatic brain injury
2026 · Neurobiology of Disease
Finds that a gene linked to brain stress makes mice more vulnerable to repeated head injuries.
- Optimization of Preclinical Rodent Research Models of Human Shock: Part 2 Trauma, Burn, and the Gut Microbiome
2026 · Shock
Tests rodent models to study trauma, burns, and gut health in ways not possible in humans.
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- Fast and slow strains of misfolded mutant superoxide dismutase 1 in familial amyotrophic lateral sclerosis
2026 · Acta Neuropathologica Communications
Shows how misfolded proteins in ALS spread quickly or slowly in mice.
- Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity
2026 · Journal of Neuroscience
Compares two gene versions to see how one speeds up tau protein damage in brain cells.
- A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells
2026 · Frontiers in Immunology
Maps epigenetic changes in immune cells after sepsis in mice of different ages and sexes.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Paramita Chakrabarty hasn't set up this page yet. Their UF Scholars profile lists their publications.