College of Veterinary Medicine
Pascual Lab
Led by David W Pascual · Infectious Diseases and Immunology
What we study
The Pascual Lab studies how vaccines work in the gut and how they can help treat autoimmune diseases. They use bacteria like Salmonella and E. coli to test new vaccine methods.
What working here is like
- Wet lab
- Bacteria & microbes
- Projects
- 3
- Papers
- 5
Current projects
Salmonella-CFA/I vaccine for autoimmune diseases
Testing if a Salmonella vaccine can help treat diseases like multiple sclerosis.
Reovirus adhesin (pσ1) for autoimmune tolerance
Using a protein from reovirus to create a fast-acting vaccine for autoimmune diseases.
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Brucella vaccines for livestock and humans
Developing vaccines to protect against Brucella infections in animals and people.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Co-requirement for B cells to protect against pulmonary wild-type Brucella melitensis challenge following mucosal vaccination with a live Brucella vaccine prototype
2026 · Frontiers in Immunology
Shows that B cells help protect mice from lung infections after nasal vaccination with a Brucella vaccine.
- Vaccination with a commensal from honey bees confers protection against vaginal Neisseria gonorrhoeae (Ng) challenge 3080
2025 · The Journal of Immunology
Finds that a bee gut bacterium can protect mice from vaginal gonorrhea infections.
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- Intervention with oral lactococcus lactis expressing CfaE (LL-CfaE) prevents or treats Sjogren’s Syndrome (SjS)-like disease in mice 3025
2025 · The Journal of Immunology
Tests whether a modified Lactobacillus strain expressing CfaE can prevent or treat Sjogren’s-like disease in mice.
- Parenteral Vaccination with a Live Brucella melitensis Mutant Protects against Wild-Type B. melitensis 16M Challenge
2024 · Microorganisms
Tests whether a modified Brucella vaccine can protect mice from wild-type infections.
- 311. Heterologous immunity and host susceptibility to emerging alphaviral infections
2023 · Open Forum Infectious Diseases
Examines how immunity to one alphavirus affects responses to another in Panama.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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