College of Medicine
Sun Lab
Led by Ramon Sun · Biochemistry and Molecular Biology
What we study
The Sun Lab studies how metabolic pathways affect brain and cancer diseases using advanced imaging and AI. They map metabolic processes in space and time to uncover disease mechanisms.
What working here is like
- Wet lab
- Computational
- Mice
- No organisms (data only)
- Coding helps
- Projects
- 3
- Papers
- 5
Current projects
Deciphering Glycogen-Driven Metabolic Dysregulations and Therapeutic Strategies in Alzheimer's Disease
Investigating glycogen metabolism in Alzheimer's disease to find new treatments.
Less Stress, More Success: Optimizing Cryosectioning Thaw Times in Spatial Metabolomics
The project tests whether short or long thaw times before cutting frozen mouse brain tissue affect the quality of metabolite maps. Students will prepare brain sections with two thaw protocols, run MALDI mass‑spectrometry imaging, and compare signal strength and tissue integrity.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 228
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Cutting Costs and Maintaining Reproducibility in Quantitative Metabolomics Using a Custom Nitrogen Blowdown Apparatus
The team designed a cheap, 3‑D‑printable nitrogen dryer for preparing tiny samples for metabolomics, tested it against commercial equipment, and shared the open‑source plans to make the technique more affordable for labs.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 71
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Structural requirements for intelligent clinical digital twins in feedback-driven care
2026 · npj Health Systems
Identifies key features for digital twins to improve patient care.
- Glycosylation orchestrates megakaryocytic fate of hematopoietic stem cells via Wnt-MUC13 signaling
2026 · Nature Communications
Finds a sugar-making enzyme controls blood cell development.
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- Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains
2026 · Cell Reports Medicine
Shows glycogen deposits link to Alzheimer’s disease progression.
- ID #580 Metabolic reprogramming by MYC drives lipid storage for medulloblastoma maintenance
2026 · Neuro-Oncology Pediatrics
Links MYC-driven tumors to metabolic changes in brain cancer.
- Hyperglycosylation is a metabolic driver of Alzheimer’s disease
2026 · Nature Metabolism
Shows how sugar molecules build up in Alzheimer's brains, using mouse and human samples.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Ramon Sun hasn't set up this page yet. You can also look them up in the UF directory (search “Ramon Sun”).