College of Medicine
Kolb Lab
Led by Ryan Kolb · Pathology
What we study
The Kolb Lab studies how Angiopoietin-like 4 (ANGPTL4) affects cancer and kidney disease. They test new treatments by combining it with immunotherapy in breast cancer and studying its role in clear cell renal cell carcinoma.
What working here is like
- Wet lab
- Cells in a dish
- No coding
- Projects
- 3
- Papers
- 5
Current projects
Targeting ANGPTL4 in combination with immunotherapy in basal-like breast cancer
Testing if combining ANGPTL4 targeting with immunotherapy improves breast cancer treatment.
The role of Angiopoietin-like 4 in clear cell renal cell carcinoma and its therapeutic potential
Exploring how ANGPTL4 affects kidney cancer and whether it can be targeted for therapy.
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Angiopoietin-like 4 as a potential therapeutic target for clear cell renal carcinoma
The lab studies ANGPTL4, a protein that may help clear cell kidney cancers grow new blood vessels. Blocking part of it reduced blood-vessel tube formation in lab tests and slowed tumor growth in one cell line, and the team identified a likely receptor for it on blood-vessel cells.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 323
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Updates on Clinical Trials and Molecular Characteristics of Locally Advanced and Oligometastatic Renal Cell Carcinoma
2026 · International Journal of Molecular Sciences
Summarizes treatments and outcomes for locally advanced and oligometastatic renal cell carcinoma.
- A Review of the Relationship Between Obesity and Immunotherapy Response in Cancer
2026 · International Journal of Molecular Sciences
Reviews how obesity affects cancer treatment responses.
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- PROTAC-mediated targeting of IKKβ and NR4A1 for AML therapy
2026 · Oncogene
- Contrasting roles of MutSα and MutLα in basal-like breast cancer 3317
2025 · The Journal of Immunology
Finds that DNA repair proteins predict survival in aggressive breast cancer.
- High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs
2025 · Frontiers in Immunology
Maps immune cell types in healthy dogs using single-cell RNA sequencing.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Ryan Kolb hasn't set up this page yet. Their UF Scholars profile lists their publications.