Agricultural and Life Sciences (IFAS)
Doore Lab
Led by Sarah Doore · Microbiology and Cell Science
What we study
The Doore Lab studies viruses of bacteria (phage) and how they infect bacterial hosts. They use methods like genetics, sequencing, and microscopy to study phage-host interactions in bacteria like Shigella flexneri.
What working here is like
- Wet lab
- Bacteria & microbes
- Coding helps
- Projects
- 2
- Papers
- 5
Current projects
Moogleviruses in Shigella flexneri
Investigating how Moogleviruses infect and replicate in Shigella flexneri.
Investigating the Host-Pathogen Interactions of Bacteriophage Sf14 and S. flexneri
The team deleted parts of the bacterial surface layer to see how a virus that infects Shigella attaches and injects its DNA, finding that the O‑antigen part of the surface blocks the virus from entering.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 119
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Genetic Engineering of Lysogenic–Lytic Switch Genes Improves Burkholderia Phage Killing Efficacy
2026 · International Journal of Molecular Sciences
Engineers genes to improve a virus's ability to kill bacteria.
- A computational investigation into the role of tRNAs encoded by Shigella phage Sf14
2025 · BMC Genomics
Uses computer models to study how a virus's genes affect infection.
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- The structure of Shigella virus Sf14 reveals the presence of two decoration proteins and two long tail fibers
2025 · Communications Biology
Maps the structure of a virus to understand its shape and parts.
- Bacterial lysis or survival after infection with phage Sf14 depends on combined nutrient and temperature conditions
2025 · PLoS ONE
Tests how temperature and nutrients affect a virus's infection cycle.
- Moo19 and B2: Structures of Schitoviridae podophages with T = 9 geometry and tailspikes with esterase activity
2024 · Science Advances
Describes the structures of two podophages, Moo19 and B2, using cryo–electron microscopy, genetics, and biochemistry.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Sarah Doore hasn't set up this page yet. You can also look them up in the UF directory (search “Sarah Doore”).