College of Medicine
Stanifer Lab
Led by Megan L Stanifer · Molecular Genetics and Microbiology
What we study
The Stanifer Lab studies how viruses evade host detection and how human cells fight infections at mucosal surfaces, using microscopy, single-cell sequencing, and organoid models.
What working here is like
- Wet lab
- Cells in a dish
- Projects
- 3
- Papers
- 5
Current projects
Role of type III interferons in promoting barrier formation at mucosal surfaces
Investigating how interferon lambda 1, 2, and 3 protect mucosal surfaces from viral infections.
STING induced IFNL2/3 protects human intestinal epithelial cells from rotavirus infection
Exploring how STING-induced interferon lambda 2 and 3 defend against rotavirus in intestinal cells.
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Using human intestinal organoids to evaluate JCV fecal/oral transmission
Studying how JC virus spreads through the gut using human intestinal organoids.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Assessment of Epithelial Barrier Integrity by TEER and FITC-Dextran Permeability Assays
2026 · BIO-PROTOCOL
Describes methods to measure how well intestinal cells block pathogens.
- Basal IFNλ2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells
2026 · PLoS Pathogens
Shows that interferon-lambda2/3 helps protect intestinal cells from viruses.
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- Subtype-specific functions of basal IFNλs
2026 · Journal of Virology
Compares how different interferon-lambda subtypes affect immune responses.
- Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction
2025 · Gut Microbes
Shows that low oxygen makes intestinal cells more vulnerable to rotavirus.
- Hypoxia Affects Stem Cell Fate in Patient-Derived Ileum Enteroids in a HIF-1α-Dependent Manner
2025 · Cells
Finds that low oxygen in the gut affects how intestinal stem cells develop.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Megan L Stanifer hasn't set up this page yet. Their UF Scholars profile lists their publications.