College of Medicine
The LaVoie Lab
Led by Matthew J LaVoie · Neurology
What we study
The LaVoie Lab studies the causes of Parkinson's disease through its rare inherited forms, focusing on genes such as Parkin and LRRK2 and how their mutations affect neurons and mitochondria.
What working here is like
- Wet lab
- Project
- 1
- Papers
- 5
Current projects
Intersection of GBA and LRRK2 in Lewy Body Dementia
Exploring how GBA and LRRK2 mutations interact in Lewy Body Dementia.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity
2026 · Journal of Neuroscience
Compares two gene versions linked to PSP and finds differences in protein production.
- Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
2026 · Molecular Neurodegeneration
Shows how LRRK2 mutations in Parkinson's disease affect iron levels and cell damage.
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- Regulation of LRRK2 activity by metabolic stress and heavy metal exposure
2025 · Brain Research
Shows how LRRK2 activity changes with metabolic stress and manganese exposure.
- Inflammatory stress on induced neurons carrying Parkinson's disease‐associated LRRK2 Mutations
2025 · Alzheimer s & Dementia
Tests if immune signals affect neurons with Parkinson's disease mutations.
- The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons
2024 · Stem Cell Reports
Tests whether LRRK2 substrates Rab8a and Rab10 cause different neuron problems in Parkinson’s disease.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Matthew J LaVoie hasn't set up this page yet. Their UF Scholars profile lists their publications.